PhD Studentships in Translational Global Health
Deadline: Thursday 13 February 2020
PhD Studentship at Aberystwyth University
Funded through the FoodBioSystems DTP, a new PhD studentship has become available, entitled ‘Repositioning histone modifying enzyme (HME) inhibitors as next-generation flukicides’. It is theorised that that histone modifying enzymes (HMEs) regulate liver fluke development and, as such, repositioned HME inhibitors (obtained from the Structural Genomics Consortium, SGC) may represent promising new, urgently-needed chemotherapies for a key disease (Fasciolosis) of animal production systems. As such, the objective of the studentship will be to investigate how HMEs affect liver fluke development by characterising F. hepatica HMEs, improving an existing image analysis model for quantifying liver fluke phenotype and motility metrics and validating liver fluke HMEs as next-generation drug targets. As a significant outcome of the project will be the development of a new image analysis model for quantifying liver fluke motility and phenotype, the student will spend at least three months of the research project embedded within the Industrial Supervisor’s facilities (Informatics Unlimited, Ltd., Cambridge) to learn the most cutting-edge techniques/methods in image analysis.
Project Supervisors are; Prof. K. Hoffmann (Aberystwyth University), Prof. A. Maule (Queens University Belfast), Dr I. Chalmers (Aberystwyth University) and Dr J. Tomczak (Informatics Unlimited Ltd.) and further details and information on how to apply are available through www.findaphd.com.
Application Deadline: Friday 6 March 2020