PhD available at the University of Edinburgh, UK:
"The evolutionary ecology of disease transmission: how are vector control programmes changing parasite life histories?”
Supervised by Prof Sarah Reece. http://www.reecelab.science
Malaria is transmitted by Anopheline mosquitoes and their control centres on long-lasting insecticide treated bed nets and indoor residual spraying. Insecticides are implicated in causing: the evolution of resistance mutations to target sites and detoxification mechanisms, shifts in feeding schedule and location, altered host preference, changes in the relative importance of different mosquito species as vectors, and shorter lifespan. Predicting how parasites will respond to such changes in vector populations requires knowledge of: (a) The impacts of interventions on parasites directly (e.g. do insecticides kill parasites?). (b) How parasite fitness is affected by changes in vector genotypes and phenotypes (e.g. insecticide resistance, biting time-of-day, lifespan, vector species). (c) How much plasticity and genetic variation exist in parasite populations for heritable traits, including fitness, that are affected by vector-control. (d) Whether parasite traits affected by vector-control are governed by trade-offs or co-variances that affect responses to selection.
This PhD will open the black box of what life inside mosquito vectors is like and develop a novel field by revealing the genetic and environmental drivers of parasite transmission to, and from, the vector. This project will use malaria parasites of rodents and mosquitoes to integrate developments from different biological disciplines into an evolutionary framework. Malaria parasites are an ideal model system because well-controlled laboratory experiments that perturb the environments parasites experience within mosquito vectors can easily be carried out. The experiments will reveal the genetic and environmental drivers of parasite transmission to, and from, the vector.
For further information and to apply, please visit this link
NERC-funded PhD studentship at University of Exeter: Antibiotic exposure impacts on fish health in natural freshwaters
Professor Charles Tyler
Dr David Bass, Centre for Enviroment Fisheries and Aquaculture Sciences (CEFAS)
Professor Joanne Cable, Cardiff University
Dr Ben Temperton, University of Exter
Dr Jackie Lighten, University of Exeter
Location: Streatham Campus, University of Exeter, Exeter, Devon.
The NERC Centre for Doctoral Training in Freshwater Biosciences and Sustainability (GW4 FRESH CDT) will provide a world-class doctoral research and training environment, for the next generation of interdisciplinary freshwater scientists equipped to tackle future global water challenges. GW4 FRESH harnesses freshwater scientists from four of the UK’s most research-intensive universities (Bath, Bristol, Cardiff and Exeter) plus world-class research organisations the Centre for Ecology and Hydrology (CEH) and British Geological Survey (BGS).
For an overview of the GW4 FRESH CDT please see website www.gw4fresh.co.uk
Note, the research projects listed are in competition with 23 other studentship projects available across the GW4 FRESH CDT Partnership. Up to 12 studentships will be awarded to the best applicants.
Microbiomes (the microbes associated with a host) are a fundamental component of human and animal health. Stressors that induce shifts in microbial communities including antibiotic exposure, have been associated with increased disease and infection in humans, but almost nothing is known in this regard for fish.
Antibiotics that target bacteria can reach microgram per litre concentrations in some UK surface waters (Monteiro and Boxall 2010) and some are now on the European Chemicals Watch list because of concern for human health through antimicrobial resistance (AMR). Bacteria can evolve resistance to natural phages (viruses) also, but doing so often involves a phenotypic trade-off such as increased susceptibility to antibiotics (Chan et al. 2018). Thus, the spread of AMR may be mitigated by host-virus interactions in natural communities. Understanding interactions between antibiotic and phage resistance in microbiome shifts and disease susceptibility is important for modelling the spread of AMR in both natural fish populations and aquaculture; as well as identifying and directing putative treatments through phage therapy.
Further details on the project and how to apply can be found here
Research Assistant Position at Durham
Applications are invited for a Research Associate to work on a MRC-funded Confidence in Concept project: “Target validation of a novel antileishmanial”
Leishmaniasis is a Neglected Tropical Disease (NTD) caused by insect-borne Leishmania spp protozoa. With increasing cases (12M), limited drugs and rising resistance, the development of new effective, non-toxic and affordable therapies is essential. Working with LifeArc (www.lifearc.org) we have identified a novel antileishmanial with both in vitro and in vivo activity. For development towards (pre)clinical trials the identification of the molecular target(s) is essential. In this project, the appointed researcher will generate drug resistant parasite lines and validate the molecular target(s) utilising genome sequencing coupled with metabolomic analyses. Success will facilitate entry into a hit to drug lead programme.
The post is fixed term for 12 months and the successful candidate will be working with Dr Paul Denny (PI) at Durham University and Dr Andy Merritt at LifeArc.
For further information and to apply, visit this link.
Fully funded PhD Studentship at University of Cambridge
A fully funded PhD studentship is available for October 2019 with Dr Catherine Merrick to study the sensing and response of Plasmodium parasites to DNA damage.
Further details are available here.
PhD Position in Evolutionary Biology
The position is available in the research group of Dr. Frida Ben-Ami,from Tel Aviv University, Israel (www.ben-ami.com). The position is available from October 15, 2018.
I am looking for a highly motivated candidate who is interested in host-parasite interactions and coevolution. In my lab, we are using the crustaceans Daphnia and their microparasites as a model system.
The successful candidate will be able to choose a project from a range of projects currently being pursued in in the lab.
• MSc degree in biology
• creative thinking
• background in evolutionary biology or ecology
• hands-on experience with experimental work
• analytical skills and good knowledge in statistics
• communication and writing skills in English
• good work ethic
Please send your application by email (all material in one PDF) to Frida Ben-Ami (email@example.com). Applications should include a CV, a list of publications and a statement about research interests (motivation letter). Please give names and email addresses of two persons who are willing to write a letter of recommendation.