Research Fellow, Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine

Salary:  £38,533 to £43,759 per annum, inclusive.
Closing Date:  Wednesday 13 June 2018
Reference:  ITD-PMBD-2018-08


We are seeking to appoint a Research Fellow to undertake research on Chagas disease and its causative agent, the protozoan parasite Trypanosoma cruzi. The project, which is funded by the MRC, aims to elucidate mechanisms of infection chronicity and pathogenesis in the digestive form of Chagas disease. We have recently discovered that T. cruzi uses the digestive tract as a permissive reservoir site in chronic infections. This results in pathological changes to the enteric muscles and nervous system, often leading to debilitating digestive megasyndromes. We plan to combine experimental infection models and bioluminescence imaging with neurological and immunological analyses to develop a better understanding of Chagas disease pathogenesis. The post will be based at the London School of Hygiene and Tropical Medicine’s headquarters in London.

The ideal candidate will have a PhD in biological sciences, extensive experience of working with animal models and advanced proficiency in molecular and cell biological techniques. A good publication record, commensurate with experience, is expected. The successful candidate will be proficient in computer applications for data processing, statistical analysis, written reports and oral presentations. Applicants with a strong background in digestive tract or parasitological research including experience in techniques for analysis of the enteric nervous system or host-pathogen interactions would be particularly welcome.

The post will be based at the London School of Hygiene and Tropical Medicine’s headquarters in London.

This full-time post is available from 1st August 2018 and is funded by the MRC for three years. The salary will be on the Academic Grade 6 scale in the range £38,533 - £43,759 per annum (inclusive of London Weighting). The post will be subject to the LSHTM terms and conditions of service.  Annual leave entitlement is 30 working days per year, pro rata for part time staff. In addition to this there are discretionary “Director’s Days”. Membership of the Pension Scheme is available.

For further details and to apply:

Any queries regarding the application process may be addressed to Please quote reference ITD-PMBD-2018-08.

W3 Professorship in Parasitology/Zoonoses available from 1st October 2018 at Justus-Liebig Universitat Giessen, Germany

Finaler Ausschreibungstext_W3 Professur für Parasitologie (in German and English)

2-year postdoc in Plasmodium molecular genetics, Cambridge University

A postdoctoral research position is available in the laboratory of Dr Catherine Merrick, working on an MRC-funded project to study the roles of G-quadruplex nucleic acid structures and the helicases that unwind them in Plasmodium falciparum. Dr Merrick's research group is currently based at Keele University and will relocate to Central Cambridge at the end of May 2018. The post will be available in Central Cambridge from June 2018.

The project will involve a range of cutting-edge 'omic-level techniques, together with molecular genetics and cell biology, and will be supported by a dedicated technician. Dr Merrick's recent work has suggested that G-quadruplexes may form a novel mechanism for controlling the transcription and recombination of var virulence genes, as well as the stability and evolution of the parasite genome as a whole. For further details, see Harris & Merrick, Plos Pathogens 2015, Stanton et al., BMC Genomics 2016 and Harris et al., AAC 2018.

Applicants should hold a PhD in molecular biology, parasitology or genomics, with skills in cell culture, molecular biology and genomics/bioinformatics. Where the successful applicant does not yet have a PhD, they will normally be under-appointed as a Research Assistant (salary of £28,936) in a Research Associate post (on the understanding that they will be appointed as a Research Associate (salary of £31,604) upon successful completion of their PhD). The higher Research Associate salary should be backdated to the submission date of their thesis or start date whichever is the later.

Other duties/responsibilities as outlined in the Further Information documents include developing and driving research objectives, writing up work for presentation and publication, assisting in the supervision of student research projects, and delivering seminars and occasional lectures. Experience of Plasmodium molecular genetics is desirable. The appointee will benefit from excellent facilities, including newly-refurbished Category-3 containment laboratories, and diverse expertise at the Cambridge Pathology Department.

For further information please contact:

Fixed-term: 2 years

Closing date 26th May 2018. Interviews will be held week commencing 11th June 2018.

More details and apply here.