Jobs

Postdoctoral Fellowship – Genome Biology Division of New England Biolabs.

The Research Department at New England Biolabs (NEB) is seeking a highly motivated individual for a Postdoctoral Fellowship in the Division of Genome Biology. The successful candidate will engage in research focused on the characterization of exosomes and small RNAs in parasitic nematodes to understand their biological role and explore their potential as diagnostic biomarkers.
Primary Responsibilities:
• Use cutting-edge methodologies to characterize exosomes and small RNAs.
• Use the latest Next Generation Sequencing (NGS) technologies for small RNA discovery.
• Develop novel diagnostic assays based on small RNA detection.
• Publish and present novel research findings in academic journals and conferences.
Qualifications and Experience:
• Recent Ph.D. in genomics, molecular biology, computational biology or related field.
• Technical expertise in NGS and large scale data analysis.
• Experience in isolating and characterizing exosomes and small RNAs.
• Interest in neglected tropical diseases.
• Ability to work independently and as part of a multidisciplinary team.
• A strong record of scientific publication.
• Effective verbal and written communication skills. 

This position offers exciting opportunities for broad research training in an interdisciplinary environment, collaboration with academic and industrial institutions, publishing in peer-reviewed journals and participation in national and international conferences.

New England Biolabs is an Equal Opportunity/ Affirmative Action Employer of Minorities, Females, Disabled and Protected Veterans

Qualified candidates may apply online at www.neb.com or contact carlow@neb.com

Four postdoctoral positions to study the cell biology and drug interactions of the trypanosome trafficking system, Dundee.

Support: The Wellcome Trust
Project director: Mark C. Field
Location: Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

We are seeking four highly motivated postdoctoral researchers with appropriate skills in molecular and cell biology to join our group and our study of the dynamics of the cell surface of trypanosomes. Our major goal is to understand the structure, function and contributions of surface proteins and transport pathways towards antigenic variation, drug sensitivity and pathogenesis. The project is seeking to take studies in this area to the next level, considering the whole cellular context in response to drugs and trafficking, by the application of proteomics, genetic screens and super-resolution microscopy. The School of Life Sciences at Dundee offers exceptional facilities, including world class proteomics, imaging, computation, access to drug screening methodology together with combined expertise in trypanosome research that is excellent. The laboratory is part of the newly formed Wellcome Trust Centre for Anti-Infectives Research. See http://bit.ly/fieldLAB for details.

Successful applicants will pursue a program under the broad title “Dynamics of the cell surface of trypanosomes”, involving predominantly molecular genetics, cell biology, proteomics, biochemistry and structural biology. They will be expected to work independently, to contribute to the teaching/training of other staff/Ph.D. students, to general laboratory duties and preparing and writing manuscripts for publication.

To apply you will have:

• An upper second or first class degree from a first rate UK University of equivalent,
• A recent Ph.D. in a relevant subject, preferably mammalian, yeast or trypanosome cell biology and/or molecular genetics,
• Experience and enthusiasm contributing to molecular cell biology projects,
• Some computer and data processing skills,
• Publications in peer-reviewed journals,
• Experience with cell culture,
• Ability to work independently and as part of a team,
• Excellent communication skills, both written and verbal.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.

To apply: Please submit a full CV and covering letter directly to mfield@mac.com. Informal inquiries welcome.

PhD Graduate Student Position: "A genomic approach to detect, monitor and track the emergence of anthelmintic drug resistance in Human Soil Transmitted Helminths (STH)", Calgary.

The University of Calgary, Faculty of Veterinary Medicine (UCVM is seeking a graduate student for a project using genomics approaches to investigate drug resistance in human soil transmitted helminths. The project will apply a number of deep amplicon sequencing and genome-wide scanning approaches that we have developed for animal parasites and apply them to track the emergence of benzimidazole drug resistance in human soil transmitted helminths.

What are we looking for:  an individual with a background in molecular ecology and/or population genomics and bioinformatics skills (or a keen desire and aptitude to learn) with a strong interest in applying their skills to a major human health problem in the developing world. The balance of specific expertise will be considered on a case-by-case basis. The preferred candidate needs to be highly motivated, enthusiastic and good team player with excellent communication skills. The work will be predominantly laboratory based but will involve working with collaborators in endemic regions with the potential fro some field work for the appropriate candidate.

 The Project:  There are currently 1.5 billion people infected worldwide with soil-transmitted helminths; roundworms such as Ascaris, Trichuris and Hookworms. The World Health Organization is currently undertaking the largest mass drug administration (MDA) program in human history to control these important pathogens. This program is dependent on a single drug class (benzimidazoles such as albendazole and mebendazole) and there is now major concern about the emergence of drug resistance. This PhD project will undertake a number of genomic approaches to detect and monitor the emergence of drug resistance in communities undergoing mass drug administration programs in endemic regions (including Ethiopia, Tanzania and Brazil).

What we offer:  The graduate student will be co-supervised by Dr John Gilleard, Professor of Parasitology  (http://www.ucalgary.ca/jsgilleard/ ) and Dr Sam Yeaman, AIHS chair in Computational Biology (http://yeamanlab.weebly.com ) at the University of Calgary. They will be part of a large interdisciplinary research group focussed on the study of anthelmintic drug resistance in parasites. The graduate student will also be a member of the NSERC-CREATE Host-parasite Interactions (HPI) graduate program which offers outstanding opportunities to undertake professional development and community outreach activities (see http://www.ucalgary.ca/hpi/).

UCVM is a new and dynamic veterinary faculty in Western Canada that has a strong commitment to comparative medicine and One Health research. UCVM is co-located with the Cummings School of Medicine providing an  outstanding infrastructure and academic environment and fostering collaborative researchbetween human and animal health . Descriptions of the Faculty and its departments can be found on the UCVM website (www.vet.ucalgary.ca). Calgary is a vibrant, multicultural city with a population of just over a million people. It is located near the Rocky Mountains, Banff National Park and Lake Louise, and offers an enormous opportunity for outdoor activities both in winter and summer.

The salary will be commensurate with the level of education and experience. For additional information and informal enquiries please contact Dr John Gilleard (jsgillea@ucalgary.ca). Interested individuals should submit a current curriculum vitae and an outline of research interests along with the names of three referees to:

Dr John Gilleard. email: jsgillea@ucalgary.ca  . Phone +1 (403) 210 6327.  Research Group website: http://www.ucalgary.ca/jsgilleard/

Review of applications will start ASAP and will be ongoing until a suitable candidate is identified.