Jobs

Research Fellow at QUB in Molecular-/Immuno Parasitology

School/Department: School of Biological Sciences

Reference: 16/105114

Closing Date: Monday 13 February 2017

Salary: £32,004 per annum

Anticipated Interview Date: Friday 3 March 2017

Duration: 2 posts available - post 1 available until 31 May 2018, post 2 available for two years.

JOB PURPOSE: To take a leading role in a research team that aims to understand the molecular basis by which helminth (worm) parasites modulate the immune responses of their ruminant host and to use this knowledge to develop molecular vaccines. The successful candidate will also assist in the development of research goals and proposals and the planning and delivery of the research activity within a specified area so that the overall research objectives of the project are met.

Jobs.ac.uk page and QUB jobs sections provide details:

http://www.jobs.ac.uk/job/AWR809/research-fellows-2-posts/

https://hrwebapp.qub.ac.uk/tlive_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=6168427Tmk&WVID=6273090Lgx&LANG=USA

Assay Development Scientist, Drug Discovery Unit, Dundee.

Assay Development Scientist, Cell-based Assays, Wellcome Trust Centre for Anti-Infectives Research.

Reference Number: SLSC0228

School: Life Sciences, Drug Discovery Unit

Grade: Grade 7 (£31,076 - £38,183)

Closing Date:  26 February 2017

The newly established Wellcome Trust Centre for Anti-Infectives Research (CAIR) at the University of Dundee is looking for a motivated and experienced biologist with expertise in cell-based assay development.

CAIR supports and works closely with the University of Dundee, Drug Discovery Unit (DDU) (www.drugdiscovery.dundee.ac.uk/) to facilitate the discovery and development of new drugs for neglected infectious tropical diseases. Together, the CAIR and the DDU form a dynamic and multidisciplinary group that covers all aspects of drug discovery up to candidate selection. The group is housed in a state-of-the-art building and has cutting-edge equipment and automation for anti-infectives research.

This role has two key aspects. In first instance, the goal is to develop new secondary assays for the kinetoplastid parasites Leishmania donovani and Trypanosoma cruzi, to improve our understanding of the relationship between in vitro observations and in vivo drug efficacy. One area of interest is the development of live-cell imaging assays for the intracellular stage of these parasites. Longer-term the aim will shift to developing new cell-based assays for other disease-causing organisms in preparation for full drug discovery programmes.

The successful applicant will be part of the CAIR/DDU biology group and report to the Parasite Screening Team Leader. In the medium term you will expected to contribute to the overall portfolio by identifying and assessing potential new approaches and projects. Opportunities are available for continuing education, conference attendance and scientific publishing, so career development opportunities will be available for the right candidate.  The post is available from 1st April 2017.

How to apply:

To apply on-line please visit: www.dundee.ac.uk/jobs

Postdoctoral Fellowship – Genome Biology Division of New England Biolabs.

The Research Department at New England Biolabs (NEB) is seeking a highly motivated individual for a Postdoctoral Fellowship in the Division of Genome Biology. The successful candidate will engage in research focused on the characterization of exosomes and small RNAs in parasitic nematodes to understand their biological role and explore their potential as diagnostic biomarkers.
Primary Responsibilities:
• Use cutting-edge methodologies to characterize exosomes and small RNAs.
• Use the latest Next Generation Sequencing (NGS) technologies for small RNA discovery.
• Develop novel diagnostic assays based on small RNA detection.
• Publish and present novel research findings in academic journals and conferences.
Qualifications and Experience:
• Recent Ph.D. in genomics, molecular biology, computational biology or related field.
• Technical expertise in NGS and large scale data analysis.
• Experience in isolating and characterizing exosomes and small RNAs.
• Interest in neglected tropical diseases.
• Ability to work independently and as part of a multidisciplinary team.
• A strong record of scientific publication.
• Effective verbal and written communication skills. 

This position offers exciting opportunities for broad research training in an interdisciplinary environment, collaboration with academic and industrial institutions, publishing in peer-reviewed journals and participation in national and international conferences.

New England Biolabs is an Equal Opportunity/ Affirmative Action Employer of Minorities, Females, Disabled and Protected Veterans

Qualified candidates may apply online at www.neb.com or contact carlow@neb.com

Four postdoctoral positions to study the cell biology and drug interactions of the trypanosome trafficking system, Dundee.

Support: The Wellcome Trust
Project director: Mark C. Field
Location: Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

We are seeking four highly motivated postdoctoral researchers with appropriate skills in molecular and cell biology to join our group and our study of the dynamics of the cell surface of trypanosomes. Our major goal is to understand the structure, function and contributions of surface proteins and transport pathways towards antigenic variation, drug sensitivity and pathogenesis. The project is seeking to take studies in this area to the next level, considering the whole cellular context in response to drugs and trafficking, by the application of proteomics, genetic screens and super-resolution microscopy. The School of Life Sciences at Dundee offers exceptional facilities, including world class proteomics, imaging, computation, access to drug screening methodology together with combined expertise in trypanosome research that is excellent. The laboratory is part of the newly formed Wellcome Trust Centre for Anti-Infectives Research. See http://bit.ly/fieldLAB for details.

Successful applicants will pursue a program under the broad title “Dynamics of the cell surface of trypanosomes”, involving predominantly molecular genetics, cell biology, proteomics, biochemistry and structural biology. They will be expected to work independently, to contribute to the teaching/training of other staff/Ph.D. students, to general laboratory duties and preparing and writing manuscripts for publication.

To apply you will have:

• An upper second or first class degree from a first rate UK University of equivalent,
• A recent Ph.D. in a relevant subject, preferably mammalian, yeast or trypanosome cell biology and/or molecular genetics,
• Experience and enthusiasm contributing to molecular cell biology projects,
• Some computer and data processing skills,
• Publications in peer-reviewed journals,
• Experience with cell culture,
• Ability to work independently and as part of a team,
• Excellent communication skills, both written and verbal.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.

To apply: Please submit a full CV and covering letter directly to mfield@mac.com. Informal inquiries welcome.

PhD Graduate Student Position: "A genomic approach to detect, monitor and track the emergence of anthelmintic drug resistance in Human Soil Transmitted Helminths (STH)", Calgary.

The University of Calgary, Faculty of Veterinary Medicine (UCVM is seeking a graduate student for a project using genomics approaches to investigate drug resistance in human soil transmitted helminths. The project will apply a number of deep amplicon sequencing and genome-wide scanning approaches that we have developed for animal parasites and apply them to track the emergence of benzimidazole drug resistance in human soil transmitted helminths.

What are we looking for:  an individual with a background in molecular ecology and/or population genomics and bioinformatics skills (or a keen desire and aptitude to learn) with a strong interest in applying their skills to a major human health problem in the developing world. The balance of specific expertise will be considered on a case-by-case basis. The preferred candidate needs to be highly motivated, enthusiastic and good team player with excellent communication skills. The work will be predominantly laboratory based but will involve working with collaborators in endemic regions with the potential fro some field work for the appropriate candidate.

 The Project:  There are currently 1.5 billion people infected worldwide with soil-transmitted helminths; roundworms such as Ascaris, Trichuris and Hookworms. The World Health Organization is currently undertaking the largest mass drug administration (MDA) program in human history to control these important pathogens. This program is dependent on a single drug class (benzimidazoles such as albendazole and mebendazole) and there is now major concern about the emergence of drug resistance. This PhD project will undertake a number of genomic approaches to detect and monitor the emergence of drug resistance in communities undergoing mass drug administration programs in endemic regions (including Ethiopia, Tanzania and Brazil).

What we offer:  The graduate student will be co-supervised by Dr John Gilleard, Professor of Parasitology  (http://www.ucalgary.ca/jsgilleard/ ) and Dr Sam Yeaman, AIHS chair in Computational Biology (http://yeamanlab.weebly.com ) at the University of Calgary. They will be part of a large interdisciplinary research group focussed on the study of anthelmintic drug resistance in parasites. The graduate student will also be a member of the NSERC-CREATE Host-parasite Interactions (HPI) graduate program which offers outstanding opportunities to undertake professional development and community outreach activities (see http://www.ucalgary.ca/hpi/).

UCVM is a new and dynamic veterinary faculty in Western Canada that has a strong commitment to comparative medicine and One Health research. UCVM is co-located with the Cummings School of Medicine providing an  outstanding infrastructure and academic environment and fostering collaborative researchbetween human and animal health . Descriptions of the Faculty and its departments can be found on the UCVM website (www.vet.ucalgary.ca). Calgary is a vibrant, multicultural city with a population of just over a million people. It is located near the Rocky Mountains, Banff National Park and Lake Louise, and offers an enormous opportunity for outdoor activities both in winter and summer.

The salary will be commensurate with the level of education and experience. For additional information and informal enquiries please contact Dr John Gilleard (jsgillea@ucalgary.ca). Interested individuals should submit a current curriculum vitae and an outline of research interests along with the names of three referees to:

Dr John Gilleard. email: jsgillea@ucalgary.ca  . Phone +1 (403) 210 6327.  Research Group website: http://www.ucalgary.ca/jsgilleard/

Review of applications will start ASAP and will be ongoing until a suitable candidate is identified.