Jobs

Postdoc - University of Glasgow, SCHISTO_PERSIST team

3 year Grade 6/7 postdoc, working within the SCHISTO_PERSIST team in Uganda and Glasgow to assess how best to improve individual treatment success.
Deadline 21st May 2017.
About the project:
Intestinal schistosomiasis caused by Schistosoma mansoni is a widespread public health problem in Uganda. A mass drug administration (MDA) based National Control Programme began to be rolled out in Uganda from 2003, with great success across the country. However hotspots, where infection prevalence, intensity and/or associated morbidity are not reducing as expected, have been detected. Here, several people do not clear their infections despite repeated praziquantel treatment. These systematic non-clearers may harbour drug resistant parasites, but when analysed in vitro they do not always differ significantly from parasites collected from individuals who clear with the standard treatment. This research post will address the question of What are the parasite and host associated risk factors for low praziquantel efficacy in s. mansoni infections? Using a combination of field and laboratory techniques they will gain insight on how we may improve individual treatment success in these S. mansoni hotspots. They will monitor parasite clearance in the field in Uganda using standard Kato-Katz and circulating cathodic antigen tests. Simple, rapid, in vitro praziquantel susceptibility tests will be performed in the field to monitor parasite drug susceptibility. They will collect data on coinfection with other parasites such as malaria and soil-transmitted helminths, and their work will be linked with an ongoing microbiome study to include intestinal microparasite coinfection data. We will collect finger prick blood samples to establish co/infection immunological responses as well as perform population level pharmacokinetic studies. Parasite samples stored by additional team members will be made available to the postdoc for them to identify potential hybrid zoonotic infections which have recently been linked with lower praziquantel efficacy. They will be part of a larger UoG team addressing how to reduce transmission and improve individual treatment success within hotspot areas supported by an excellent Ugandan field team. Strong understanding and experience in molecular work are required for this role. Field experience in sample and data collection in resource poor settings is highly desirable.

Postdoctoral Research Associate, Keele University - School of Life Sciences

We are currently recruiting a Research Associate with experience in molecular biology and eukaryotic cell culture to work on a Newton Fund research project at Keele University on the protozoan parasite in Egyptian camels. Applicants should have an interest in global veterinary health and a PhD in molecular biology, biochemistry or parasitology. The study will involve molecular analysis of parasites isolated from blood samples collected in Egypt and in vitro drug screening assays on the parasite Trypanosoma evansi. This post will require some travel to Egypt, including a 3-6 month stay in Alexandria during the second year of the project to facilitate setting up a molecular parasitology laboratory with Egyptian collaborators. Full training will be provided where required.

For informal enquiries please contact Dr Helen Price (h.price@keele.ac.uk).

For full post details please visit: www.keele.ac.uk/vacancies, or see http://www.jobs.ac.uk/job/AYM152/research-associate

Postdoctoral Fellowship – Genome Biology Division of New England Biolabs.

The Research Department at New England Biolabs (NEB) is seeking a highly motivated individual for a Postdoctoral Fellowship in the Division of Genome Biology. The successful candidate will engage in research focused on the characterization of exosomes and small RNAs in parasitic nematodes to understand their biological role and explore their potential as diagnostic biomarkers.
Primary Responsibilities:
• Use cutting-edge methodologies to characterize exosomes and small RNAs.
• Use the latest Next Generation Sequencing (NGS) technologies for small RNA discovery.
• Develop novel diagnostic assays based on small RNA detection.
• Publish and present novel research findings in academic journals and conferences.
Qualifications and Experience:
• Recent Ph.D. in genomics, molecular biology, computational biology or related field.
• Technical expertise in NGS and large scale data analysis.
• Experience in isolating and characterizing exosomes and small RNAs.
• Interest in neglected tropical diseases.
• Ability to work independently and as part of a multidisciplinary team.
• A strong record of scientific publication.
• Effective verbal and written communication skills. 

This position offers exciting opportunities for broad research training in an interdisciplinary environment, collaboration with academic and industrial institutions, publishing in peer-reviewed journals and participation in national and international conferences.

New England Biolabs is an Equal Opportunity/ Affirmative Action Employer of Minorities, Females, Disabled and Protected Veterans

Qualified candidates may apply online at www.neb.com or contact carlow@neb.com

Four postdoctoral positions to study the cell biology and drug interactions of the trypanosome trafficking system, Dundee.

Support: The Wellcome Trust
Project director: Mark C. Field
Location: Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

We are seeking four highly motivated postdoctoral researchers with appropriate skills in molecular and cell biology to join our group and our study of the dynamics of the cell surface of trypanosomes. Our major goal is to understand the structure, function and contributions of surface proteins and transport pathways towards antigenic variation, drug sensitivity and pathogenesis. The project is seeking to take studies in this area to the next level, considering the whole cellular context in response to drugs and trafficking, by the application of proteomics, genetic screens and super-resolution microscopy. The School of Life Sciences at Dundee offers exceptional facilities, including world class proteomics, imaging, computation, access to drug screening methodology together with combined expertise in trypanosome research that is excellent. The laboratory is part of the newly formed Wellcome Trust Centre for Anti-Infectives Research. See http://bit.ly/fieldLAB for details.

Successful applicants will pursue a program under the broad title “Dynamics of the cell surface of trypanosomes”, involving predominantly molecular genetics, cell biology, proteomics, biochemistry and structural biology. They will be expected to work independently, to contribute to the teaching/training of other staff/Ph.D. students, to general laboratory duties and preparing and writing manuscripts for publication.

To apply you will have:

• An upper second or first class degree from a first rate UK University of equivalent,
• A recent Ph.D. in a relevant subject, preferably mammalian, yeast or trypanosome cell biology and/or molecular genetics,
• Experience and enthusiasm contributing to molecular cell biology projects,
• Some computer and data processing skills,
• Publications in peer-reviewed journals,
• Experience with cell culture,
• Ability to work independently and as part of a team,
• Excellent communication skills, both written and verbal.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.

To apply: Please submit a full CV and covering letter directly to mfield@mac.com. Informal inquiries welcome.