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Three postdoc positions, Merrick lab, Keele Centre for Applied Entomology and Parasitology

3-year and 5-year MRC and ERC funded postdocs

Closing Date  -   Feb 5th, 2017

These posts represents an exciting opportunity to join the laboratory of Dr Catherine Merrick.  Two newly funded projects will focus on:

a) G-quadruplex nucleic acid structures and the helicases that unwind them in Plasmodium falciparum.  Our recent work suggests that these may form a novel mechanism for controlling the transcription and recombination of var virulence genes, as well as the stability and evolution of the parasite genome as a whole.  For further details, see Harris & Merrick, Plos Pathogens 2015 and Stanton et al., BMC Genomics 2016.  A range of cutting-edge ‘omic-level techniques, together with molecular genetics, will be employed and this 3-year project will be supported by a dedicated technician.

b) DNA replication dynamics in Plasmodium falciparum.  Dr Merrick recently developed a novel technique to follow DNA replication in malaria parasites at the whole cell, genomic, and single-molecule levels (see Merrick, Malar J. 2015).  A large-scale ERC project will now examine replication and the cell cycle at several stages of the Plasmodium lifecycle, using a range of cutting-edge techniques in molecular genetics and genomics.  The 5-year project will employ 2 postdocs and be supported by a dedicated technician.

Applicants should hold a PhD in genomics, molecular biology or parasitology, with skills in cell culture, molecular biology and genomics/bioinformatics.  Experience of Plasmodium molecular genetics is desirable but not essential.  The appointee will benefit from the excellent facilities and diverse expertise of malaria biologists at Keele’s Centre for Applied Entomology and Parasitology (CAEP).

For further information please contact: c.merrick@keele.ac.uk

http://www.keele.ac.uk/caep/people/catherinemerrick/

For full post details and to apply please see posts KU00000361 and 362 at: www.keele.ac.uk/vacancies

The webpages of the Centre for Applied Entomology and Parasitology (CAEP) are found here.

Technician, Keele University, Molecular Genetics in the human malaria parasite

Closing date - 2nd Feb 2017

Salary £26,052

3 years fixed term in the first instance with the possibility of extension beyond this period.
This post represents an exciting opportunity for a technician to join the laboratory of Dr Catherine Merrick, supporting two new projects on DNA replication and G-quadruplex biology in Plasmodium falciparum.  Responsibilities will include basic laboratory maintenance - ordering and managing consumables, preparing reagents and media, maintaining equipment, databases and archives, ensuring health and safety compliance and the correct disposal of hazardous waste, etc. - as well as supporting postdoctoral researchers by performing molecular biology and parasite cell culture in a Category-3 containment laboratory.
Applicants should hold an undergraduate degree in a biological discipline and should have some experience of working in a biological research lab.  Experience with cell culture, molecular biology and/or bioinformatics is highly desirable.
For further information please contact: c.merrick@keele.ac.uk
http://www.keele.ac.uk/caep/people/catherinemerrick/

For full post details and to apply please see post KU00000380 at: www.keele.ac.uk/vacancies

The webpages of the Centre for Applied Entomology and Parasitology (CAEP) are found here.

Research Fellow at QUB in Molecular-/Immuno Parasitology

School/Department: School of Biological Sciences

Reference: 16/105114

Closing Date: Monday 13 February 2017

Salary: £32,004 per annum

Anticipated Interview Date: Friday 3 March 2017

Duration: 2 posts available - post 1 available until 31 May 2018, post 2 available for two years.

JOB PURPOSE: To take a leading role in a research team that aims to understand the molecular basis by which helminth (worm) parasites modulate the immune responses of their ruminant host and to use this knowledge to develop molecular vaccines. The successful candidate will also assist in the development of research goals and proposals and the planning and delivery of the research activity within a specified area so that the overall research objectives of the project are met.

Jobs.ac.uk page and QUB jobs sections provide details:

http://www.jobs.ac.uk/job/AWR809/research-fellows-2-posts/

https://hrwebapp.qub.ac.uk/tlive_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=6168427Tmk&WVID=6273090Lgx&LANG=USA

Four postdoctoral positions to study the cell biology and drug interactions of the trypanosome trafficking system, Dundee.

Support: The Wellcome Trust
Project director: Mark C. Field
Location: Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

We are seeking four highly motivated postdoctoral researchers with appropriate skills in molecular and cell biology to join our group and our study of the dynamics of the cell surface of trypanosomes. Our major goal is to understand the structure, function and contributions of surface proteins and transport pathways towards antigenic variation, drug sensitivity and pathogenesis. The project is seeking to take studies in this area to the next level, considering the whole cellular context in response to drugs and trafficking, by the application of proteomics, genetic screens and super-resolution microscopy. The School of Life Sciences at Dundee offers exceptional facilities, including world class proteomics, imaging, computation, access to drug screening methodology together with combined expertise in trypanosome research that is excellent. The laboratory is part of the newly formed Wellcome Trust Centre for Anti-Infectives Research. See http://bit.ly/fieldLAB for details.

Successful applicants will pursue a program under the broad title “Dynamics of the cell surface of trypanosomes”, involving predominantly molecular genetics, cell biology, proteomics, biochemistry and structural biology. They will be expected to work independently, to contribute to the teaching/training of other staff/Ph.D. students, to general laboratory duties and preparing and writing manuscripts for publication.

To apply you will have:

• An upper second or first class degree from a first rate UK University of equivalent,
• A recent Ph.D. in a relevant subject, preferably mammalian, yeast or trypanosome cell biology and/or molecular genetics,
• Experience and enthusiasm contributing to molecular cell biology projects,
• Some computer and data processing skills,
• Publications in peer-reviewed journals,
• Experience with cell culture,
• Ability to work independently and as part of a team,
• Excellent communication skills, both written and verbal.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.

To apply: Please submit a full CV and covering letter directly to mfield@mac.com. Informal inquiries welcome.

PhD: 3 positions in molecular parasitology, Life Science Research Centre, University of Ostrava, Czech Republic

Closing date - 31 January 2017

Positions available from September 1st, 2017 in the laboratory of Molecular protozoology (Dr. Vyacheslav Yurchenko, http://www1.osu.cz/~yurchenko/)

  1. To study the limits of trypanosomatids' biodiversity using molecular phyloghenetic and phylogenomic methods.

Requirements: fluent English, knowledge of molecular phylogenetic principles and approaches. Basic bio-computing experience (e.g. genome and transcriptome analysis) is advantageous.

Recent publications:

Kostygov, A., Dobáková, E., Grybchuk-Ieremenko, A., Váhala, D., Maslov, D., Votýpka, J., Lukeš, J., Yurchenko, V. Novel trypanosomatid –bacterium association: evolution of endosymbiosis in action. mBio, 2016, 7(2): e01985-15. PMID: 26980834.

Votýpka, J., d'Avila-Levy, C., Grellier, P., Maslov, D., Lukeš, J., Yurchenko, V. New approaches to systematics of Trypanosomatidae: criteria for taxonomic (re)description. Trends Parasitol., 2015, 31: 460-469. PMID: 26433249.

  1. To study the molecular mechanisms governing translation in Blastocrithidia sp.

Requirement: fluent English, advanced molecular biology skills (DNA, RNA, protein analyses, genome manipulations). Basic bio-computing experience (e.g. genome and transcriptome analysis) is advantageous.

Recent publication:

Záhonová, K., Kostygov, A., Ševčíková, T., Yurchenko, V., Eliáš, M. An unprecedented non-canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr. Biol., 2016, 26(17): 2364-2369. PMID: 27593378.

  1. To study novel virulence factors in Leishmania infection

Requirements: fluent English, advanced molecular biology skills (DNA, RNA, protein analyses, genome manipulations). Basic bio-computing experience (e.g. genome and transcriptome analysis) is advantageous.

Recent publications:

Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793.

Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLOS Path., 2015, 11(8): e1005127. PMID: 226317207.

Kraeva, N., Ishemgulova, A, Lukeš, J., Yurchenko, V. Tetracycline-inducible gene expression system in Leishmania mexicana. Mol. Biochem. Parasitol., 2014, 198: 11-13. PMID: 25461484.

How to apply:

Please send your Resume and Cover/motivation letter to Dr. Vyacheslav Yurchenko by January 31, 2017. Do not forget to indicate position you are applying for. E-mail: vyacheslav.yurchenko@osu.cz

Laboratory of Molecular protozoology is a part of the Life Science Research Centre at the Faculty of Science, University of Ostrava focused on biological and biomedical research in the areas of functional genomics and bioinformatics. For more information, visit the lab web page at www1.osu.cz/~yurchenko/

PhD Graduate Student Position: "A genomic approach to detect, monitor and track the emergence of anthelmintic drug resistance in Human Soil Transmitted Helminths (STH)", Calgary.

The University of Calgary, Faculty of Veterinary Medicine (UCVM is seeking a graduate student for a project using genomics approaches to investigate drug resistance in human soil transmitted helminths. The project will apply a number of deep amplicon sequencing and genome-wide scanning approaches that we have developed for animal parasites and apply them to track the emergence of benzimidazole drug resistance in human soil transmitted helminths.

What are we looking for:  an individual with a background in molecular ecology and/or population genomics and bioinformatics skills (or a keen desire and aptitude to learn) with a strong interest in applying their skills to a major human health problem in the developing world. The balance of specific expertise will be considered on a case-by-case basis. The preferred candidate needs to be highly motivated, enthusiastic and good team player with excellent communication skills. The work will be predominantly laboratory based but will involve working with collaborators in endemic regions with the potential fro some field work for the appropriate candidate.

 The Project:  There are currently 1.5 billion people infected worldwide with soil-transmitted helminths; roundworms such as Ascaris, Trichuris and Hookworms. The World Health Organization is currently undertaking the largest mass drug administration (MDA) program in human history to control these important pathogens. This program is dependent on a single drug class (benzimidazoles such as albendazole and mebendazole) and there is now major concern about the emergence of drug resistance. This PhD project will undertake a number of genomic approaches to detect and monitor the emergence of drug resistance in communities undergoing mass drug administration programs in endemic regions (including Ethiopia, Tanzania and Brazil).

What we offer:  The graduate student will be co-supervised by Dr John Gilleard, Professor of Parasitology  (http://www.ucalgary.ca/jsgilleard/ ) and Dr Sam Yeaman, AIHS chair in Computational Biology (http://yeamanlab.weebly.com ) at the University of Calgary. They will be part of a large interdisciplinary research group focussed on the study of anthelmintic drug resistance in parasites. The graduate student will also be a member of the NSERC-CREATE Host-parasite Interactions (HPI) graduate program which offers outstanding opportunities to undertake professional development and community outreach activities (see http://www.ucalgary.ca/hpi/).

UCVM is a new and dynamic veterinary faculty in Western Canada that has a strong commitment to comparative medicine and One Health research. UCVM is co-located with the Cummings School of Medicine providing an  outstanding infrastructure and academic environment and fostering collaborative researchbetween human and animal health . Descriptions of the Faculty and its departments can be found on the UCVM website (www.vet.ucalgary.ca). Calgary is a vibrant, multicultural city with a population of just over a million people. It is located near the Rocky Mountains, Banff National Park and Lake Louise, and offers an enormous opportunity for outdoor activities both in winter and summer.

The salary will be commensurate with the level of education and experience. For additional information and informal enquiries please contact Dr John Gilleard (jsgillea@ucalgary.ca). Interested individuals should submit a current curriculum vitae and an outline of research interests along with the names of three referees to:

Dr John Gilleard. email: jsgillea@ucalgary.ca  . Phone +1 (403) 210 6327.  Research Group website: http://www.ucalgary.ca/jsgilleard/

Review of applications will start ASAP and will be ongoing until a suitable candidate is identified.